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renal impairment may require monitoring The one-week half-life of both components enables true once-weekly dosing while maintaining relatively stable plasma concentrations throughout the dosing interval, contributing to consistent therapeutic effects and potentially improved tolerability compared to shorter-acting agents
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When combining the two, expect nausea to be most pronounced during dose escalation periods, particularly when both compounds are being increased in close succession
Accessed June 20, 2024.
J Biochem
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